I see a lot of talk online with this particular event id relating to Exchange. This is not an Exchange server. It's an IIS server running a web page for an inhouse application.
I don't really know how to debug it. It only happens very randomly and I'm unsure of the catalyst so far. One...
asp.net
authentication
authorization
communication
debugging
domain controller
error handling
event id
exchange
iis
in-houseapplication
process information
requests
stack trace
system error
trust relationship
unhandled exception
virtual path
web apps