Microsoft recently released an update kb3086255 which disables two old style DRM's Securom and Safedisc.
This means that any games still using this old style of Digital Rights Management will not work under Windows 10.
This is to address security concerns and if your truly desperate to play...
Securom stops responding so NWN 2 doesn't load. Anyone have any other problems with securom?
edit: Sorry, forgot to try compatability mode and run as admin, the game runs now.