This appears to be an interesting Update Tuesday. Lots of updates there.
Seems that more & more the updates/hotfixes is in regard to remote code execution. Which is the probably the worst possible scenario that any computer user would want to be in. Probable Total loss of control of one's computer, if the attack is successful. A reinstall (or recent recovery from a backup) will likely be necessary.
It's an all day deal for me, but I make sure that all of my installs are updated on the 2nd Tuesday of every month.