Hi, Newbie here and it is not even my own PC. My kid has a Toshiba Mini Notebook (NB255) with Windows 7 Starter. Starting yesterday we can no longer open any programs on the Notebook. The system boots and the desktop loads but only a small number of system? programs load and then nothing else. If you click on any desk top icon or even go to the programs list and choose folders etc they all respond the same way with the ERROR Message "windows cannot access specified device, path or file .........". I have booted into Safe Mode and all is OK. I have scanned with Microsoft Essentials, SuperAntiSpyware and Malwarebytes AntiMalware and all seams clean. I have Restored the system back to three different Restore points but still get the Errors. The same thing happened a few weeks ago after I did an Update but I was able to fix it by Restoring the system back to a date before the update. This time we have not done any updates but when I checked the Update Log it showed a number of Updated that we did not perform. The system is set to notify of updates but not to download or install them? On top of Security Essentials I have OnLine Armor Free on board but cannot open that in Safe Mode anyway (also cannot turn on Real Time Protection in Microsoft Essentials) or in normal mode - cause I get the Error Message in Normal Mode. BIG BIG HELP ................. I am totally stuck here and have no idea how to fix the Notebook.