Excel 2010 Errors

We work for ITO-Client-Management team. There are some issues while using the MS-Excel 2010 which we work on daily basis. File size is 12.5MB and has 42600 plus rows and 17 columns.
When a formula (i.e.: COUNTIF, VLOOKUP) is run, it takes lot of time (30min) for compilation. The worksheet hangs for long time (30min). In Task Manager it shows “Not Responding”. Either it ends hanging or shows a white screen.
When option “Move or Copy” is used. We face the below error alert in image.

When a file save option is used, we face an error “Document Not Saved” for two-three times. Finally gets saved after putting lot of efforts.
When shortcut option Ctrl+D is used for Fill down, it takes more time compared to normal MS-EXCEL 2003. Many such actions which were shift in earlier versions are extremely slow in latest versions.
Please provide us with appropriate solution, early as possible. On an urgent basis.

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