I have the following setup: Windows 7 Professional 64 bit AMD Quad Core 2.2 Ghz 8 GB Ram The issue is that when running more than just a few applications it will get to a point where I am unable to open any new applications. When trying to open non Microsoft programs, nothing happens. When trying to open a Microsoft program (such as an Office app) i will get an error message: "There is not enough memory or disk space" When running the memory monitor in Windows 7, there is less than 50% memory utilization (usually about 3 - 3.5 GB of ram being used) and hardly any CPU utlization (less than 25% on all 4 cores). Sometimes closing all of the running applications will correct the issue and then I am able to open a new application. Other times I must restart the computer to clear up the issue. I have run Malwarebytes to look for spyware that might be causing the issue. It does not find any malware that is creating this 'memory leak' if that is what it is. FYI - this box originally came with Vista 64 bit and I performed a clean install of Windows 7 Pro 64 bit. Does anyone have any suggestions or tips/tools that I can run to try to find the cause of this?