I have been having this problem for a little while now and up until yesterday I had no idea what was causing it. My Problem: The Windows Explorer (Not IE) will randomly lock up and the only way to fix the problem is to CTRL+Atl+Delete and open the Task Manager. I don't even have to kill anything with the Task Manager, all I have to do is open it. What Is Causing the Problem: At first I thought maybe something was wrong with windows. But I swapped my old HDD for and SSHD and the problem was still there. Obviously nothing to do with windows. So I thought maybe it was something I had installed on my computer (which it is). My mouse drivers are what is causing the problem. I have a Gigabyte M6900 gaming mouse and anytime that is plugged in, windows goes crazy and the explorer freezes when it wants to. I tried uninstalling the drivers and having windows re-install them but that didn't work at all. Considering just getting a new mouse but wanted to see if anyone had any suggestions on fixing the problem that maybe I haven't tried yet.