my keyboard and mouse get stuck

I have windows 7 ultimate installed on my computer and it has been apparently normal for a long time. But recently my keyboard and mouse simultaneously get stuck. It get stuck only in the middle of something and I have to reboot the system to bring the mouse and keyboard to normal. The mouse won't respond to any type of movement or click nor do the keyboard responds. Even the caps lock or number lock keys are non-responding as if plugged off. At the same time the system do run perfectly normal for eg: if I was on some installation it will go to completion even when the keyboard and mouse are dead.
Is it hardware problem, a bad sector, a virus or something like that.
My system runs on a 1gb ram and asus m2nvm motherboard.

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