Hi
I'll second what Patcook said.
My PC has an SSD for my C:\ drive, and the only thing I have installed on it is Windows 10 and a few small programs like Malwarebytes.
All my other software, all my photos, music, games and graphics software are on other drives.
The advantage is that if Windows crashes, I get a virus, or have some issue I don't know how to fix, I can restore my Windows install in about 22 minutes, instead of hours messing around.
What ever happens, my data is safe and my software doesn't need to be reinstalled.
I use EaseUS Todo backup, a free easy to use program.
It will make a System Image of my drive in about 20 minutes.
If I had all my stuff on that drive it would take hours.
In addition anything that you don't want to lose should be copied to an external location, DVDs, an external hard drive, or cloud storage.
Don't use backup software just copy and paste the data to safe storage.
You never know what can happen, my computer has been hit by lightning twice!!!
Mike