Been running Win 7 since Beta on my same hardware, no problems. I am now running a purchased copy of Win 7 Ultimate 64bit. Yesterday, my mouse abruptly stopped responding. Here is what I have already done. 1. Test the mouse on my Win 7 Ult. 32bit laptop - works fine 2. Test another USB mouse on desktop with reboot - no response 3. Check for driver updates - none found 4. Uninstall driver, reboot with mouse plugged in - no improvement 5. Noticed that intellipoint updated the day prior. Uninstalled intellipoint - no improvement Reinstalled package intellipoint, no improvement. windows updated to the latest one again. nothing 6. Uninstalled other windows update from the day prior - no improvement 7. Tested USB ports with both a thumb-drive and printer - All USB ports are working fine and windows installs the peripherals for use with no issue. 8. Contemplated going office space on the computer... but I have a client needing a product in 2 days. The mouse that has worked fine all along is a Microsoft Wireless Optical Mouse 2.0 I've also tested it with 2 different wired logitec mice. All plug and play into my 32bit laptop with no problem. Any ideas?