Thanks for your suggestions. I looked again in start up and found it was hiding in a Microsoft start up item. I disabled it and deleted the entry from the Registry. Seems ok now !
I had some malware on my laptop (Windows 7 Home Premium) which I removed. I also stopped some things like Skype loading automatically. But when I do a start up the system is trying to load the following file - c:\program data\EsopInfo\Esopjafo.dat. I've no idea what this is and can't find any...