I've had problems with Registry Mechanic before. I lost my links to several of my System Tools. Defrag, System Restore, and some of my administrative tools were gone. There was a bunch of others too. That was on XP Pro x64 Edition several years ago though. Maybe it isn't too bad but I'll never use it again. I took the suggestion of numerous experts in this forum and now use CCleaner.I use Registry Mechanic, which has never given me problems. However, after a couple of days and reinstalling several programs, everything appears to have tempered down. Photoshop and a couple of others don't respond as well as they had, but nothing major. Seems to be a memory thing where they can't remember the settings I designate.
Still not thoroughly happy, but at least I'm getting some work done. Will do a clean install this weekend when I have some time.