Relocating User Profiles/Storage

I previously relocated my user profiles (and all corresponding files) to a separate partition under Windows 8 and would like to do the same with Windows 10.

Can anyone confirm if the below method still works? I know there were many downsides an it was not supported by Microsoft - they advocated for using the 'Location' tab of each folder, but that doesn't seem to work for OneDrive, and I would like to have my Outlook OSTs on a separate partition also.
User Profiles - Relocate to another Partition or Disk

Some insight would be appreciated.

Thanks in advance!

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