Yeah the interface isn't the best, but there's nothing you really need to tweak to increase the security. I believe there is some more aggressive scanning, but I'll need to wait until I'm home to confirm. I've never used any secondary tools, but you can run windows defender along side it. The URL extension is better than any browser add-on since it's running at a much lower level than any browser add-on (it's driver driven)
I still use AdBlock, Ghostery, HTTPSanywhere and privacy badger in chrome and EMET in max security mode.