Windows 10 Boot from USB flash drive only with FAT32 and no multi-boot support?

[pstein]

1. I have a (new) Acer Swift notebook which does not allow to switch/enable Legacy BIOS mode.
   So I can only disable "Secure Boot" and use UEFI.
   
   However my bootable, GPT and NTFS formatted USB flash drive is NOT recognized or even bootable.
   It works on other computers.
   
   I read that FAT32 should be used.
   Is this really a requirement? No NTFS possible?
   
   Furthermore I read that the bootable USB flash drive MUST NOT contain two boot-variants for 64bit AND 32bit. Only stand-alone 64bit bootloader is allowed.
   
   Is this true?
   
   What about two-in-one bootable USB flash drives which allow booting Legacy-BIOS OR UEFI?
   are these devices accepted?
   
   Thank you
   Peter

 

[Neemobeer]

NTFS should work fine although FAT32 is more widely accepted on varying system firmware. If the USB is formatted with the GPT partition scheme the firmware has to be set to UEFI and if it's formatted with MBR firmware needs to be in legacy or also referred to as CSM. All computers since the early 2000s are 64 bit capable so there really is no reason for a 32bit bootloader, but it should work regardless.