From a command prompt you can delete it with the reg utility. If you want to delete that key you can type
REG DELETE HKCR\Adobe.adobebridge\Desmond /f you can throw this in a batch file or powershel and you can easily call this from within pretty much any programming language.
If you want to collapse the regedit view completely you can delete the following two keys when regedit is closed. It re-writes them upon exit.
REG DELETE HKCU\SOFTWARE\Microsoft\Windows\CurrentVersion\Applets\Regedit /v LastKey /f
REG DELETE HKCU\SOFTWARE\Microsoft\Windows\CurrentVersion\Applets\Regedit /v View /f