So you have decided the file is associated with a program you want to run?
Do you know what program it is?
You might check to see if there is an option to repair an application's install, and sometimes that might be in the Programs and Features Panel in the Control Panel. If it is a driver, you might be able to reinstall it to repair. The next step would be to uninstall the device and then let Windows find it again. You may see an option to remove all drivers for that device, which I would do just so some corrupt file will be removed and replaced.
Did you check what the service depends on and if those services are running?
Since this seems to be a third party application, possibly a video driver or some part of one, running a...