I've used both CCleaner and Defraggler for years.
I love Defraggler because it will let you defragment specific files in just a few minutes.
When I do a video file that is many gigabytes in size it really makes a noticeable difference if I defrag it before I edit or run it.
So I do this a lot and I defrag the files I'm working on every day.
Mike
"I've used both CCleaner and Defraggler for years." Me too (so old my first computer was a Sinclair Spectrum

I do some video editing too but hadn't thought to defrag the files. I can imagine that it's a good idea especially after some heavy editing w. changing scene sequence and such.
These third-party, open source utilities generally are a lot more accommodating "
...Defraggler because it will let you defragment specific files..." than their MS counterparts and do more with less or no fanfare, so to speak.