Unfortunately Res Evil 5 worked on mine first try in Dx10 mode....no additional compatiblity settings at all, so not really sure where your issue lies...what build drivers ya using for the GPU? That said as impressive as the graphics are, I found the controls system clumsy when you need to reload or use objects during a fight, probably no worse than its previous titles in the series though. It could be something in protection so prehaps maybe try to use a no-dvd crack incase thats the issue....although that often stops online play working etc.
then it is just my luck then..
i posted in another forum (forgot which) about this and someone stepped up saying a friend of his..
which is running a quad core processor also, have the same problems as I do..
is your processor a quad core, Highwayman?
Yea I got the Q6600 (Tip: click the small PC TV screen icon by names for system specs)
well you could try FORCE OFF option on AA in the nvidia driver pages, as an alternative, which is how mine is currently set btw.
I'm gonna be installing resident evil 5 maybe tomorrow or so and I'm running windows 7 rtm 64-bit. I'll see if I get the same problem as you.
For further reading I suggest browsing this guide:-
TweakGuides.com - Nvidia Forceware Tweak Guide
Right click desktop / Nvidia control Panel / Manage 3d settings
Everything that can be fiddled with is all in there, since when you install drivers they always force the default settings which can be often wrong....for example \"AntiAliasing - Mode\" if set to off disables it entirely, making it unavailable to use by any game etc.
For further reading I suggest browsing this guide:-
TweakGuides.com - Nvidia Forceware Tweak Guide