The simple answer is yes.
To keep it simple adjust share permissions to everyone full control (folder properties, sharing tab, Advanced Sharing button, share this folder.
Then set your actual NTFS permission to be as granular as you would like using the Security Tab and making sure that you add the user(s) that you want to have a certain level of access to a folder as you desire. Keep in mind that NTFS permissions impact both local users (users who are setting at the machine) as well as users who are comming at you over the network. Most restrictive permissions win. Be careful about removing users or user groups as well as setting anything to deny, deny wins always.
It is often easier to assign permissions based on group membership...