I was having the same problem as everyone else here. CommandCenter4 would not open. My fix was simple. I had to remove the "Dell" folder from the C:/windows/twain_32 folder. That is all it took. I didn't delete the folder, I just moved to my desktop to see if that fixed it and it did. I guess my old Dell printer installed that folder a while back and it was interfering some how. Every thing seems to be working just fine now.