Based on the information you've provided, it seems like the issue could be related to the network connectivity or replication latency. Here are some troubleshooting steps you can try:
1. Check the DNS settings on the affected machines: Make sure that the DNS server entries are pointing to the correct IP addresses of your domain controllers. You can also try flushing the DNS cache using the command "ipconfig /flushdns" on the affected machines.
2. Check the file replication service (FRS) logs: Use the command "repadmin /showrepl" to check the FRS logs and make sure that there are no replication errors. If there are any errors, you'll need to troubleshoot the FRS service.
3. Check the DFS client settings: Make sure that the DFS client service is enabled and running on the affected machines. You can check this through the Services console.
4. Check the permissions on the SYSVOL folder: Make sure that the Authenticated Users group has read access to the SYSVOL folder and that the GPOs are stored in the correct location.
5. Check the time synchronization: Make sure that the time on the domain controllers and the affected machines are synced. You can check this by running the command "w32tm /query /source" on the affected machines.
6. Check the firewall settings: Make sure that the firewall settings on the affected machines are not blocking any necessary ports for the domain controllers.
If none of these steps resolve the issue, you can try creating a new GPO from scratch with a different name and see if it's applied without any issues. If it is, then the issue may be related to the current GPOs.
The only problem i could find is that repadmin /showrepl today give me 2 errors for each DCs (yesterday wasn't).
Here the result of the command repadmin /showrepl :
"Repadmin: running command /showrepl against full DC localhost
Premier-Site-par-defaut\DC1
DSA Options: IS_GC
Site Options: (none)
DSA object GUID: xxxxxxxxxxxxxxxxxxxxxxxxx
DSA invocationID: xxxxxxxxxxxxxxxxxxxxxxxx
==== INBOUND NEIGHBORS ======================================
DC=ourdomain,DC=fr
Premier-Site-par-defaut\DC2 via RPC
DSA object GUID: xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Last attempt @ 2023-04-28 14:15:14 was successful.
CN=Configuration,DC=ourdomain,DC=fr
Premier-Site-par-defaut\DC2 via RPC
DSA object GUID: xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Last attempt @ 2023-04-28 13:46:55 was successful.
CN=Schema,CN=Configuration,DC=ourdomain,DC=fr
Premier-Site-par-defaut\DC2 via RPC
DSA object GUID: xxxxxxxxxxxxxxxxxxxxxxxxxxxx
Last attempt @ 2023-04-28 13:46:55 was successful.
DC=DomainDnsZones,DC=ourdomain,DC=fr
Premier-Site-par-defaut\DC2 via RPC
DSA object GUID: xxxxxxxxxxxxxxxxxxxxxxx
Last attempt @ 2023-04-28 13:46:55 was successful.
DC=ForestDnsZones,DC=ourdomain,DC=fr
Premier-Site-par-defaut\DC2 via RPC
DSA object GUID: xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Last attempt @ 2023-04-28 13:46:55 was successful.
DsReplicaGetInfo() failed with status 8453 (0x2105):
Replication access was denied.
DsReplicaGetInfo() failed with status 8453 (0x2105):
Replication access was denied."