I suggest you unplug all drives, then test them one at a time. It could be one of them causes trouble, as to cause others not to work. And since the whole computer is integrated, disk players can affect USB too. If you have SATA cables, be sure not to twist them or force them in 90 degrees, they need "air". Preferably, you could test them in another computer?
On the other hand, I do find it unlikely that two drives stop working at the same time, independently, adding USB to it. I would look for the problem in the background, like Saltgrass writes, How old is the system? Something may simply have blown on your motherboard.
Another option could be your PSU = Power Supply Unit. Old and getting grey, perhaps loosing vitality? Loosing power in a computer means... loosing.
A third option could be, motherboard drivers have become corrupt. That could be because of a power failure that knocked something out, or a virus attack, or something. The BIOS can also be attacked, showing "whatever". I recommend a full scan with your Antivirus, plus Malwarebytes.
Windows problems are one thing. But since you can't boot from BIOS, it's another thing. A BIOS update?