I was pretty hesitant about jumping onto Windows 7 since I was still running XP. But I couldn't resist the idea of using the next Windows free for a year so I downloaded and installed 7100. I am now up to 7201 and wanted to post what apps I am using successfully. Bear in mind I am using 64-bit also and my principal computer usage is for home admin, email, web use, watching videos/movies, listening to music, controlling my BOSS GT-10 guitar multieffects controller, and a bit of 3-d gaming in COD4. Unless noted otherwise, all of the following apps are installed and working fine. 7-zip 64-bit edition - WinZIP alternative Adobe Reader 9.1.1 BOSS GT-10 driver - installed in VISTA compatibility mode - 64-bit driver for BOSS GT-10 CCleaner - system cleanup tool. Cleans IE, Chrome, and log files OK. Does not have ability yet apparently on either Win7 or 64-bit to cleanup hotfix installers like it can on XP Creative Audio Drivers 2.18.0013 Creative Console Launcher 2.61.09 - these both support my X-Fi Extreme Gamer just fine Diskeeper 2009 Professional - alternative disk defrag - nice and zippy installed in 64-bit mode DU Meter 4.01.R3076 - bandwidth meter - installed in 32-bit mode Google Chrome - installed itself in 32-bit mode GT-10 Librarian - 32-bit patch manager software for BOSS GT-10 GT-10 FxFloorboard - 32-bit patch editor software for BOSS GT-10 MagicDisc 2.7.106 - mounting/accessing DVD images - works fine. This version is listed on the PowerISO web site as having Win 7 compatibility McAfee Virus Scan Enterprise and Anti-Spyware Enterprise 8.7 - both installed native 64-bit mode and work fine MP3Tag 2.43 - MP3 file tag editor, works fine NVIDIA 186.08 drivers for Geforce 8800 GTS card Paint.NET 3.36 - image editor program - installed as 32-bit, works fine Powertab Editor 1.7 - reading/editing softcopy music scores - works fine Quicktime 188.8.131.52 - works fine VUZE 184.108.40.206 - torrent client - works fine ZoomPlayer 6.00 MAX - media player application with ffdshow and other codecs, works great! I have it setup to use the MS EVR renderer and playback and sound are great under 64-bit CoreTemp 0.99.4 64-bit - works great, shows me CPU temp COD4 - nothing to report yet since I haven't tried running it. It wanted to install into the Program Files (x86) directory and when I did that Punkbuster did not update. I forced it to install into the Program Files directory instead and also set VISTA compatibility. I also manually downloaded PBSETUP.EXE from evenbalance and run that from a separate directory rather than using the one that comes with the game. I've been doing this for a couple years now so that I know what version of PB is installed on my system for various games. So that's my list. While probably not required, I ran the installers for all of these 'as Adminstrator' in most cases. I usually ran things without selecting any compatability mode except as noted above.