Hi
My process is to run, CCleaner, Malwarebytes, Defraggler, and SuperAntiSpyware to start with.
Then I use the tools in CCleaner to turn off anything that I don't need to have start at boot.
Make sure you have plenty of free disk space for your swap file.
And you can run...
SFC /scannow
...from the command prompt to see if it finds any problems.
Mike