So i changed the drive letter from "E:" to "D:" on my second drive. Obviously some programs broke and when i select "open with", even if i go to location and select it; it doesn't work. Obvious solution is to fix in "Registry" With my previous SSD; "D:" was the default letter. I changed SSD and it attributed an "E:" but things worked. I will change SSD again, and windows might attribute it a "D:" and things will work. Until then should i: - Change to "E:" again, - Re-install what's not working Or is there another system wide fix i could know? I am asking cause its good to know in case it happens again.