The fact that it's on a secondary drive could imply it is a baddy, but not necessarily. First thing to do would be to scan your system thoroughly, with the Antivirus you have, and Malwarebytes.
If your system works well, you could use the safe way and rename the folder, then reboot, and test various programs. If you can't rename it, Unlocker
http://www.emptyloop.com/unlocker/ usually works fine, or Take Ownership
Link Removed.
Another aspect is to use a restore point, Control Panel\All Control Panel Items\Backup and Restore. Take a restore point "day before the problem". But then you need to be careful with what updates you are offered later.
It may be kinky. The main thing is if your system works - if it does, is there a need to do anything?