Hi Jim,
Specifics of the drivers you want to remove may be a help. Also have you tried changing the file extension from (usually) .sys to .bak or a.n.other name? That will break them and prevent them from loading at the next boot.
I don't think changing the extension is an option and I don't think they're loading at boot time. Windows won't let me do anything in these 'system' directories even with the UAC off.
Specifically the files, left behind after a Compro TV card was uninstalled are:
C:\Windows\System32\DriverStore\FileRepository\comprohid.inf_amd64_neutral_4d2b630faf7cce49
C:\Windows\winsxs\Manifests\amd64_microsoft-windows-m..comproxy-deployment_31bf3856ad364e35_6.1.7600.16385_none_4ab2877b1e16b4a7.manifest
C:\Windows\System32\DriverStore\FileRepository\comprohid.inf_amd64_neutral_4d2b630faf7cce49\ComproHID.cat
C:\Windows\System32\DriverStore\FileRepository\comprohid.inf_amd64_neutral_4d2b630faf7cce49\comprohid.inf
C:\Windows\System32\DriverStore\FileRepository\comprohid.inf_amd64_neutral_4d2b630faf7cce49\comprohid.PNF
C:\Windows\System32\drivers\ComproHID64.sys
C:\Windows\System32\DriverStore\FileRepository\comprohid.inf_amd64_neutral_4d2b630faf7cce49\ComproHID64.sys
(Output is from the Everything search tool)
Regards,
Jim.