Hi,
You're post is quite confusing but we may be able to help.

You say you are trying to remove the hard drive, but you don't say
WHICH drive by letter designation. Which drive and letter are you having the problem with?
C:, E:, J:, K:, I:?
Also, when asking a question like this it's customary to at least provide us with some basics. What version of Windows are you running? What Make/Model is the computer? Is it a desktop PC or a laptop? Is it an OEM PC (Dell, HP, Acer, Toshiba)? Self-built PC or Custom-built PC?
It's hard to solve a problem you've had for weeks or months without this kind of information.
If you didn't know which drive is the Bootdrive (C: drive), then who added all these extra drives to your computer? Did you buy it with all these drives from someone?
There a number of repair tools you can use to fix this problem, but if you remove the C: drive and it doesn't boot from the other drives, this is normal as only
ONE DRIVE, THE C: BOOTDRIVE is responsible for booting Windows (commonly referred to as
Drive #0). If any of your other drives are USB drives, which it appears to be, none of those drives are capable of booting Windows, so of course removing the C: drive will cause your system not to boot.
Thanks,
<<<BIGBEARJEDI>>>