For most people who have good internet browsing habits, and don't install a bunch of random software I would say Defender and Malwarebytes Full Version (yes it's worth purchasing, the full version gives you realtime protection).
However if you are a user who installs lots of random software, downloads lots of files (especially from peer to peer file transfer programs), visits porn sites, etc you may want a full fledged Antivirus program (I personally recommend ESET NOD32).
That is my opinion, it varies person to person completely depends on your internet habits. Remember no antivirus program is 100%, new viruses come out all the time and if they are not in your antivirus programs definitions (or dictionary if you will) they won't be...