erez … aside from
kemical's knowledgeable answer … what you're wanting to do really depends on several factors.
first point
(and not everyone subscribes to this strategy):
one should keep enough spare room on their boot-drive so all programs can be installed on the boot-drive. there are other patrons out there who prefer keeping the boot-drive only for operating-system files and, thereby, delegating a secondary reserved partition for only software installs … maintaining a third partition (or separate drive) for personal files.
also, if you run out of room on boot-drive … consider uninstalling some programs you no longer use … or think about expanding the partition.
second point … really depends on the software you have installed:
for instance … ransomfree is a ransomware sentry. it actually creates what are termed "honey-pots" in certain regions of the environment. these folders contain files which should not be moved or renamed. if you need more information on this … i'd suggest you contact cybereason to inquire.
third point:
the process of you renaming/moving folders 'n files could manifest unforeseen consequences … choose the wrong folder, and you may very well be staring at a dead monitor or drive some morning.
fourth point:
microsoft performs it's patch-tuesday requiem … suddenly, you are hit with bsod or a suspended "windows-throbber" with tiny dots circling inexorably. this may not have happened had you not renamed a certain file/folder.
the following is only a suggestion,
erez … perhaps keep the
"tidying up" only within your personal-files partition/server.
best wishes to you.