I agree with Henk; check your mouse and headphones on another working laptop. If they are Ok; you might have sustained a hardware failure on the Motherboard. You might consider running hardware diagnostics on that laptop if you haven't done so. If the mouse and headphones work on another laptop, this would be the smart thing to try.
You can test your hardware using these links:
MEMORY TEST: Memory Diagnostics HARD DRIVE TEST: http://www.carrona.org/hddiag.htm Also, did your Alienware laptop come pre-loaded with Win10 from Dell, or did you upgrade it to Win10 from an earlier version of Windows (Win7/8/8.1)? It's helpful to provide us with more information on your computing environment than just a short paragraph with a couple of sentences.
Another good test that's free and pretty easy is to download and run
UbuntuLTS Linux and run a
LiveCD version, which you can create for about
$0.20 (Twenty cents U.S.). This will not install any software on your hard drive but will let bypass your W10 and allow you to test your mouse and headphones on your laptop without using Windows at all. If your mouse and headphones work on Ubuntu Linux; almost certainly you have a corrupted or infected W10 installation on that computer. There are many software solutions that we can then help you with to remedy that. However, if your mouse and headphones which you've hopefully tested on another laptop by the time you get to this point, fail on Ubuntu, chances are your ports (1 or more) have failed on that laptop Motherboard, and you'll need to get it serviced and replaced. This can be an expensive repair, as Alienware Motherboards are quite expensive; could be in the $500-$1,500 US range! Here's the link to download Ubuntu:
Download Ubuntu Desktop | Download | Ubuntu Lastly, if you test your hardware using my above links and find no failures on either your RAM sticks or your Hard Drive, and you test your mouse and headphones on another computer and know they are good, but fail to work in Ubuntu Linux, it's a good bet your Mobo has failed as I indicated above. All of this will probably take you a week or more to do if you are an experienced computer user, more if you are not and need to get help.
Let us know how it goes!
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