You can update or reinstall the audio drivers. You can also download the latest drivers from the Lenovo support website. Make sure to check the playback devices by right-clicking the sound icon in the taskbar and see if your internal speaker or headphones are listed; set them as the default if they are. Running the "Playing Audio" troubleshooter in Settings can help identify and fix problems too.
For the USB issues, check Device Manager for any problems with USB controllers and update the drivers if necessary. Disable power saving for USB Root Hubs by going into their properties in Device Manager. Look for BIOS updates from Lenovo, as these can resolve hardware compatibility issues. If disabling the USB 3.0 root solves some problems, you can keep it that way, but be aware it might limit the speeds of USB 2.0 devices.