A couple of thoughts for you; you mention that you are running
BOTH Kaspersky & Windows Defender (WD) concurrently on your Server2016. This is not possible; as you can only be running 1 AV program at a time. If you are running Kaspersky, then you need to go into your System Tray or the WD app itself and disable Real-time Protection and Firewall, in order to let Kaspersky be the primary.
I have several issues with Kaspersky with my Customer-base, and have mentioned it several times here and on other forums. Most of the techs here don't have problems with it. In the interest of troubleshooting, our Admins usually recommended temporarily disabling your Kaspersky, and making sure to enable only WD, and rescan for viruses. Continue to run
MALWAREBYTES are recommended by Neemo, make sure you download the v3.x version which is the newest and only available for 14-day trial.
If you are running the Server2016 product for a business, and are testing it for deployment at your home, you have a lot more control over what products you run, and to my knowledge, there are no Fortune500 companies currently running it. There are many reasons for this, but, here is one possible reason; see this link:
Senate Gets Ready to Ban Kaspersky Products as FBI Interviews Company's US Employees
You may wish to stick with WD as your Server-side AV, but personally I still recommend a 3rd party AV or AV-suite such as EMSIsoft, Avast, Norton, or TrendMicro. By the way, the file you have appears to be a script-virus, which usually comes in via E-mail via a MS OFFICE attachment such as Word, Excel, or PowerPoint. You should also carefully check your E-mail client settings, especially if you are running Exchange Server on your Server2016 PC, as well as your router settings for incoming TCP/UDP traffic. Don't know who your ISP is either, but you should be aware that several of them, including Spectrum and Comcast do not allow for fully secured encryption over their lines; specifically SSLx protocols. If you are running Exchange Server on the same PC as your Server2016, this is no Bueno! No large businesses ever do this due to the issues of non-separation and single-point of failure. If your main Server goes down, so does your E-mail server!! Most companies can't afford to do this. This happened to Microsoft in 1998 with the I LOVE YOU VIRUS, and their E-mail went down for 4 days for 95,000 employees and lost millions of $$.
If you've contracted a script-virus on your Server, you have to look at the full security picture of your network environment. If you DO plan on deploying this server into a business environment, you should look at purchasing an enterprise-wide security appliance, such as from Symantec, CA, or Cisco. We used to use a Cisco PIX firewall appliance on the TDC of our corporate network, and it did a pretty good job.
Food for thought.
Best of luck,
<<BIGBEARJEDI>>