The direct disk start = autoplay not working is known, but can you start a disk from within PowerDVD? That is, start PowerDVD, then click the "Open a disk" or "Play a disk". Does that work?
About IE10, what's the error code you get?
I would suggest you run a full scan with your Antivirus program, plus a run with Malwarebytes. May be, you have some boogies there. No one never knows what they can do.
And please, do answer the question Digerati made, If it earlier worked on this machine. It's very important to know.
Best wishes, in all ways and aspects. Hope we get it working.