Windows 10 Mouse problems with Windows 10

I installed Windows 10 three days ago. Since then I have had numerous problems with my mouse and track ball. What happens is this: I am working and then the mouse or track ball are unresponsive. I then try whichever device I am not using and it is also unresponsive. I then try my wacom tablet and it works--every time. After using the wacom, even if I only touch the tablet to show it works, the mouse and trackball are responsive again. I have tried changing USB ports (I had 6 free ports and tested them all), uninstalling/reinstalling mouse and trackball, and updating Windows (latest was last night) but none of these has fixed the problem. Usually the mouse doesn't work at boot up, so I tap the wacom and then the mouse works for an hour or two. Sometimes it will stop working every couple of minutes--it is very frustrating. I am using a Microsoft optical mouse and a mouse-trak trackball.