If this happened recently and if System Restore is enabled and you can go back far enough, restore the computer to an earlier date using Safe Mode.
Restart the computer and start tapping the F8 key, select the Safe Mode with Command Prompt option. If you are asked to select an operating system, use the arrow keys to select the correct one and press Enter. Log on as an administrator or with an account that has administrator credentials. At the command prompt, type %systemroot%\system32\rstrui.exe and then press Enter. Follow the prompts to restore the computer to an earlier date.
After successfully restoring the system, run your ‘anti’ programs to clean up any residual ‘nasties’ in the user folder(s). When the computer is clean...